Mesenchymal Stem Cells And Autism

Based on laboratory studies and clinical trials for other conditions msc are the leading cell type used to treat auto immune disorders and inflammation 28 30.

Mesenchymal stem cells and autism.

Due to the particular immune and neural dysregulation observed in asds. Umbilical cord mesenchymal stem cell infusions were safe and generally well tolerated. To the authors knowledge this is the first single arm phase i ii clinical trial of repeated dose umbilical cord mesenchymal stem cells administration in children diagnosed with autism spectrum disorder asd. In fact one recent study using a mouse strain bred to have autistic like symptoms showed that transplantation of mesenchymal stem cells resulted in a reduction in stereotypical behaviors a decrease in cognitive rigidity and an improvement in social behavior.

Mesenchymal stem cell transplantation for the treatment of autism spectrum disorders is a novel approach that deserves further investigation however substantial methodological and theoretical. Why treat autism with mesenchymal stem stromal cells msc. The primary sources of the msc in clinical trials are bone marrow fat tissue and umbilical cord tissue 24 27.